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DM51 impurity 1-d<sub>9</sub>

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Targets Recommended: P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-143987S

DM51 impurity 1-d9

Drug Metabolite Isotope-Labeled Compounds Others

DM51 impurity 1-d₉ is the deuterium labeled DM51 impurity 1[1].

DM51 impurity 1-d9	Drug Metabolite Isotope-Labeled Compounds	Others
DM51 impurity 1-d₉ is the deuterium labeled DM51 impurity 1[1].

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase ^[1].

HY-B0131S2

Prostaglandin E1-d9 Alprostadil-d<sub>9sub>; PGE1-d<sub>9sub>	Isotope-Labeled Compounds Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E1-d₉ is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

HY-143951S

Disulfiram impurity 1-d10

Drug Metabolite Isotope-Labeled Compounds Others

Disulfiram impurity 1-d₁₀ is the deuterium labeled Disulfiram impurity 1[1].
HY-143956S

Fluorofenidone impurity 1-d3

Drug Metabolite Isotope-Labeled Compounds Others

Fluorofenidone impurity 1-d₃ is the deuterium labeled Fluorofenidone impurity 1[1].
HY-143974S

Imiquimod impurity 1-d6

Drug Metabolite Isotope-Labeled Compounds Others

Imiquimod impurity 1-d₆ is the deuterium labeled Imiquimod impurity 1[1].
HY-144913S

Bempedoic acid impurity 1-d4

Isotope-Labeled Compounds Others

Bempedoic acid impurity 1-d₄ is the deuterium labeled Bempedoic acid impurity 1[1].
HY-131251

Cetirizine 3-chloro impurity

Drug Metabolite Others

Cetirizine 3-chloro impurity is an impurity of Cetirizine 3-chloro ^[1].
HY-131269

Febuxostat impurity 7

Drug Metabolite Others

Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1].
HY-131270

Febuxostat impurity 8

Drug Metabolite Others

Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1].
HY-131271

Febuxostat impurity 6

Drug Metabolite Others

Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1].

*Disulfiram impurity* 1-d10**	Drug Metabolite Isotope-Labeled Compounds	Others
Disulfiram impurity 1-d₁₀ is the deuterium labeled Disulfiram impurity 1[1].

*Fluorofenidone impurity* 1-d3**	Drug Metabolite Isotope-Labeled Compounds	Others
Fluorofenidone impurity 1-d₃ is the deuterium labeled Fluorofenidone impurity 1[1].

*Imiquimod impurity* 1-d6**	Drug Metabolite Isotope-Labeled Compounds	Others
Imiquimod impurity 1-d₆ is the deuterium labeled Imiquimod impurity 1[1].

*Bempedoic acid impurity* 1-d4**	Isotope-Labeled Compounds	Others
Bempedoic acid impurity 1-d₄ is the deuterium labeled Bempedoic acid impurity 1[1].

Cetirizine 3-chloro impurity	Drug Metabolite	Others
Cetirizine 3-chloro impurity is an impurity of Cetirizine 3-chloro ^[1].

*Febuxostat impurity* 7**	Drug Metabolite	Others
Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1].

*Febuxostat impurity* 8**	Drug Metabolite	Others
Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1].

*Febuxostat impurity* 6**	Drug Metabolite	Others
Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1].

HY-143960S

*Givinostat impurity* 1-d10 hydrochloride**	Drug Metabolite Isotope-Labeled Compounds	Others
Givinostat impurity 1-d₁₀ (hydrochloride) is the deuterium labeled Givinostat impurity 1 hydrochloride[1].

HY-143986S

DM50 impurity 1-d9

Drug Metabolite Isotope-Labeled Compounds Others

DM50 impurity 1-d₉ is the deuterium labeled DM50 impurity 1[1].

*DM50 impurity* 1-d9**	Drug Metabolite Isotope-Labeled Compounds	Others
DM50 impurity 1-d₉ is the deuterium labeled DM50 impurity 1[1].

HY-131272

Febuxostat dicarboxylic acid impurity	Drug Metabolite	Others
Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1].

HY-131273

Febuxostat amide impurity

Drug Metabolite Others

Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1]
HY-143986S1

DM50 impurity 1-d9-1

Drug Metabolite Isotope-Labeled Compounds Others

DM50 impurity 1-d₉-1 is the deuterium labeled DM50 impurity 1[1].

Febuxostat amide impurity	Drug Metabolite	Others
Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM ^[1]

*DM50 impurity* 1-d9-1**	Drug Metabolite Isotope-Labeled Compounds	Others
DM50 impurity 1-d₉-1 is the deuterium labeled DM50 impurity 1[1].

HY-133777

*Ciprofibrate impurity* A**	PPAR	Cancer
Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate (Win35833) is a potent peroxisome proliferator, increases the phosphorylation level of the PPARalpha ^[1].

HY-100663

*Gefitinib impurity* 2**	EGFR	Others
Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity ^[1] .

HY-134686

*Edoxaban impurity* 4**	Factor Xa Thrombin	Cardiovascular Disease
Edoxaban impurity 4 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K_is of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention ^[1] .

HY-133774

*Trityl olmesartan medoxomil impurity* III**	Drug Metabolite	Others
Trityl olmesartan medoxomil impurity III is an impurity of Trityl olmesartan medoxomil. Trityl olmesartan medoxomil is an intermediate of Olmesartan medoxomil ^[1].

HY-141410

Fluticasone dimer impurity	Drug Metabolite	Others
Fluticasone dimer impurity is a dimeric impurity of Fluticasone Propionate ^[1]. Fluticasone propionate is a corticosteroid with comparatively high receptor affinity and topical activity .

HY-131255

Ziprasidone amino acid Ziprasidone impurity C; Ziprasidone open ring impurity	5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone amino acid (Ziprasidone Impurity C) is an impurity of Ziprasidone. Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist. Ziprasidone exhibits potent effects of antipsychotic activity ^[1].

HY-131265

*Mesalamine impurity* P**	PPAR PAK NF-κB	Inflammation/Immunology Cancer
Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB ^[1].

HY-W178868S

Lodoxamide impurity 1-d5

Drug Metabolite Isotope-Labeled Compounds Others

Lodoxamide impurity 1-d₅ is deuterium labeled n-Ethyl-2-hydroxyacetamide.

*Lodoxamide impurity* 1-d5**	Drug Metabolite Isotope-Labeled Compounds	Others
Lodoxamide impurity 1-d₅ is deuterium labeled n-Ethyl-2-hydroxyacetamide.

HY-131276

Olmesartan lactone impurity	Angiotensin Receptor	Cardiovascular Disease
Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study ^[1] .

HY-400785

*Dapagliflozin impurity* A**	Others	Cancer
Dapagliflozin impurity A (Compound A) is a dapagliflozin peroxide, a genotoxic impurity, can cause damage to human genetic material at very low concentrations, leading to genetic mutations and possibly tumorigenesis ^[1].

HY-131256

*Cetirizine Impurity* C**	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine Impurity C is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist ^{[1] ^{^{[2] ^.}}}

HY-131256A

*Cetirizine Impurity* C dihydrochloride**	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine Impurity C dihydrochloride is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist ^{[1] ^{^{[2] ^.}}}

HY-133780

*Afatinib impurity* 11**	EGFR Autophagy	Cancer
Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC₅₀s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR ^wt, EGFR ^L858R, EGFR ^L858R/T790M and HER2, respectively ^[1].

HY-121899

1-Oxo Ibuprofen Ibuprofen EP impurity J	Drug Metabolite	Others
1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively ^[1] .

HY-17020S

Miglustat-d9 N-Butyldeoxynojirimycin-d<sub>9sub>; NB-DNJ-d<sub>9sub>; OGT 918-d<sub>9sub>	Isotope-Labeled Compounds Glucosylceramide Synthase (GCS)	Neurological Disease
Miglustat-d9 is the deuterium labeled Miglustat. Miglustat (N-Butyldeoxynojirimycin) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1) ^[1] .

HY-110363

Miglustat-d9 hydrochloride N-Butyldeoxynojirimycin-d<sub>9sub> hydrochloride; NB-DNJ-d<sub>9sub> hydrochloride; OGT 918-d<sub>9sub> hydrochloride	Isotope-Labeled Compounds Glucosylceramide Synthase (GCS)	Neurological Disease
Miglustat-d₉ (hydrochloride) is the deuterium labeled Miglustat (hydrochloride). Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1)[1][2].

HY-B1260S3

Cetrimonium-d9(bromide) CTAB-d<sub>9sub>; Cetyltrimethylammonium-d<sub>9sub> bromide; Hexadecyltrimethylammonium-d<sub>9sub> bromide	Isotope-Labeled Compounds	Others
Cetrimonium-d₉ (bromide) is the deuterium labeled Cetrimonium bromide[1]. Cetrimonium bromide (CTAB) is an amine based cationic quaternary surfactant, is one of the components of the topical antiseptic Cetrimide.

HY-107495

*Betahistine EP Impurity* C** NSC19005	Histamine Receptor	Inflammation/Immunology
Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine ^[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA) .

HY-B1290S1

2-Phenylethanol-d9 Phenylethyl alcohol-d<sub>9sub>; Phenethyl alcohol-d<sub>9sub>; Benzyl carbinol-d<sub>9sub>	Bacterial Virus Protease Antibiotic	Infection
2-Phenylethanol-d₉ is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.

HY-B1431S2

Butylparaben-d9 Butyl parahydroxybenzoate-d<sub>9sub>; Butyl paraben-d<sub>9sub>; Butyl 4-hydroxybenzoate-d<sub>9sub>	Isotope-Labeled Compounds	Infection
Butylparaben-d₉ (Butyl parahydroxybenzoate-d₉; Butyl paraben-d₉) is a deuterium labeled Butylparaben (HY-B1431).

HY-15459S1

Cabazitaxel-d9 XRP6258-d<sub>9sub>; RPR-116258A-d<sub>9sub>; taxoid XRP6258-d<sub>9sub>	Isotope-Labeled Compounds Microtubule/Tubulin Autophagy	Cancer
Cabazitaxel-d₉ is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

HY-116790BS

(±)-Penbutolol-d9 (Rac)-Penbutolol-d<sub>9sub>; (±)-Isopenbutolol-d<sub>9sub>	5-HT Receptor Adrenergic Receptor Isotope-Labeled Compounds	Others
(±)-Penbutolol-d₉ is the deuterium labeled (±)-Penbutolol[1].

HY-17501S

Bambuterol-d9 hydrochloride (±)-Bambuterol-d<sub>9sub> hydrochloride; KWD-2183-d<sub>9sub> hydrochloride	Adrenergic Receptor	Endocrinology
Bambuterol-d₉ (hydrochloride) is the deuterium labeled Bambuterol. Bambuterol ((±)-Bambuterol) hydrochloride is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline.

HY-116790BSA

(±)-Penbutolol-d9 hydrochloride (Rac)-Penbutolol-d<sub>9sub> hydrochloride; (±)-Isopenbutolol-d<sub>9sub> hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology
(±)-Penbutolol-d₉ (hydrochloride) is a deuterium labeled (±)-Penbutolol hydrochloride. (+)-Penbutolol hydrochloride is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1].

HY-B1037S2

Salbutamol-d9 Albuterol-d<sub>9sub>; AH-3365-d<sub>9sub>	Isotope-Labeled Compounds Adrenergic Receptor	Neurological Disease Endocrinology
Salbutamol-d₉ is the deuterium labeled Salbutamol. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).

HY-B0269S

Rifapentine-d9 DL 473-d<sub>9sub>; Cyclopentylrifampicin-d<sub>9sub>	Bacterial Antibiotic	Infection
Rifapentine-d₉ is the deuterium labeled Rifapentine. Rifapentine (DL 473) is an antibiotic compound used in the treatment of tuberculosis.

HY-B1037S3

Salbutamol-d9 acetate Albuterol-d<sub>9sub> acetate; AH-3365-d<sub>9sub> acetate	Adrenergic Receptor
Salbutamol-d₉ (acetate) is the deuterium labeled Salbutamol[1]. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).

HY-14865S

Omadacycline-d9 PTK 0796-d<sub>9sub>; Amadacycline-d<sub>9sub>	Bacterial Isotope-Labeled Compounds	Others
Omadacycline-d9 (PTK 0796-d9; Amadacycline-d9) is the deuterium labeled Omadacycline (HY-14865) that can be used as the internal standard for the analysis of Omadacycline ^[1].

HY-10237S

Boceprevir-d9 EBP 520-d<sub>9sub>; SCH 503034-d<sub>9sub>	Isotope-Labeled Compounds HCV Protease HCV SARS-CoV	Infection
Boceprevir-d₉ is the deuterium labeled Boceprevir. Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay[1][2][3][4][5]. Boceprevir inhibits SARS-CoV-2 3CLpro activity[6].

HY-113270AS

Actinine-d9 chloride γ-Butyrobetaine-d<sub>9sub> hydrochloride; Deoxycarnitine-d<sub>9sub> hydrochloride	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Actinine-d₉ chloride is the deuterium labeled Actinine chloride. Actinine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat[1][2].

HY-B0399S

L-Carnitine-d9 (R)-Carnitine-d<sub>9sub>; Levocarnitine-d<sub>9sub>	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease Metabolic Disease
L-Carnitine-d₉ is the deuterium labeled L-Carnitine. L-Carnitine (Levocarnitine) is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2].

HY-17369BS

Tirofiban-d9

L700462-d<sub>9sub>; MK383-d<sub>9sub>
Isotope-Labeled Compounds Integrin Cardiovascular Disease

Tirofiban-d₉ is deuterium labeled Tirofiban.

HY-B0228S14

Adenosine-d9 Adenine riboside-d<sub>9sub>; D-Adenosine-d<sub>9sub>	Isotope-Labeled Compounds	Others
Adenosine-d₉ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5 Publications Verification	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[1] .

HY-W011474

Geranylgeraniol	Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[1] .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively ^[1].

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). ^[1].

HY-W778546

7-epi-10-Deacetyl baccatin III	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus baccata L.	Others
7-epi-10-Deacetyl baccatin III can be isolated from the degradation impurities in Docetaxel (HY-B0011) ^[1].

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations ^[1].

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Disease Research Fields Selaginella tamariscina (P. Beauv.) Spring Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[1] .

HY-W778547

7-epi-10-Oxo-10-deacetyl baccatin III 10-Dehydrobaccatin V	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus baccata L.	Others
7-epi-10-Oxo-10-deacetyl baccatin III (10-Dehydrobaccatin V) can be isolated from the degradation impurities in Docetaxel (HY-B0011) ^[1].

HY-B0504S

Creatinine-d3 NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-112023

Lumisterol 3 (>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP impurity C	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D ^[1].

HY-N8549

5β-Dihydrocortisone	Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver ^[1].

HY-N10530

Lactodifucotetraose Difucosyllactose ; 2′,3-Difucosyllactose	Natural Products Polysaccharides Classification of Application Fields Animals Other Diseases Disease Research Fields Saccharides	Others
Lactodifucotetraose (Difucosyllactose) is a tetrasaccharide isolated from human milk. Lactodifucotetraose constitutes of D-glucose, 1 D-galactose, and L-fucose ^[1].

HY-126848

Diclofenac acyl glucuronide D-1-O-G	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Drug Metabolite Endogenous Metabolite
Diclofenac acyl glucuronide (D-1-O-G) is a major bile metabolite directly involved in small intestinal ulceration in rats ^[1].

HY-134529

D-Ribofuranose1-dihydrogenphosphate Ribose 1-phosphate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Ribofuranose1-dihydrogenphosphate, also known as ribose 1-phosphate, is the material for the synthesis of 5-fluorouracil (FUra) by uridine phosphorylase ^[1].

HY-134529A

D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine Ribose 1-phosphate dicyclohexanamine	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine, also known as ribose 1-phosphate, is the material for the synthesis of 5-fluorouracil (FUra) by uridine phosphorylase ^[1].

HY-N8549A

5-Dihydrocortisone	Structural Classification Classification of Application Fields Cardiacglycosides Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
5-Dihydrocortisone is a 5-Dihydrocortisone with mixture of isomers. 5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver ^[1]

HY-B0471

Phenylephrine hydrochloride Maximum Cited Publications 9 Publications Verification (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Cardiovascular Disease Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
(R)-(-)-Phenylephrine hydrochloride is a selective *α₁-adrenoceptor* agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-N0096

Rotundine (-)-Tetrahydropalmatine; L-Tetrahydropalmatine	Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	5-HT Receptor Dopamine Receptor
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of *5-HT_1A* with an IC₅₀ of 370 nM.

HY-N5102

D-(+)-Fucose	Ipomoea muricata Source classification Other Diseases Plants Disease Research Fields Convolvulaceae Saccharides	Others
D-(+)-Fucose is a nonmetabolizable analogue of l-arabinose. D-(+)-Fucose prevents growth of Escherichia coli B/r on a mineral salts medium plus l-arabinose by inhibiting induction of the l-arabinose operon ^[1]. D-fucose is a potent inducer of beta-methylgalactoside permease (MGP) .

Cat. No.	Product Name	Chemical Structure

HY-143987S

DM51 impurity 1-d9

DM51 impurity 1-d₉ is the deuterium labeled DM51 impurity 1[1].

HY-B0131S2

Prostaglandin E1-d9
Prostaglandin E1-d₉ is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

HY-143951S

Disulfiram impurity 1-d10

Disulfiram impurity 1-d₁₀ is the deuterium labeled Disulfiram impurity 1[1].
HY-143956S

Fluorofenidone impurity 1-d3

Fluorofenidone impurity 1-d₃ is the deuterium labeled Fluorofenidone impurity 1[1].
HY-143974S

Imiquimod impurity 1-d6

Imiquimod impurity 1-d₆ is the deuterium labeled Imiquimod impurity 1[1].
HY-144913S

Bempedoic acid impurity 1-d4

Bempedoic acid impurity 1-d₄ is the deuterium labeled Bempedoic acid impurity 1[1].
HY-143960S

Givinostat impurity 1-d10 hydrochloride

Givinostat impurity 1-d₁₀ (hydrochloride) is the deuterium labeled Givinostat impurity 1 hydrochloride[1].
HY-143986S

DM50 impurity 1-d9

DM50 impurity 1-d₉ is the deuterium labeled DM50 impurity 1[1].
HY-143986S1

DM50 impurity 1-d9-1

DM50 impurity 1-d₉-1 is the deuterium labeled DM50 impurity 1[1].
HY-W178868S

Lodoxamide impurity 1-d5

Lodoxamide impurity 1-d₅ is deuterium labeled n-Ethyl-2-hydroxyacetamide.

HY-17020S

Miglustat-d9
Miglustat-d9 is the deuterium labeled Miglustat. Miglustat (N-Butyldeoxynojirimycin) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1) ^[1] .

HY-110363

Miglustat-d9 hydrochloride
Miglustat-d₉ (hydrochloride) is the deuterium labeled Miglustat (hydrochloride). Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1)[1][2].

HY-B1260S3

Cetrimonium-d9(bromide)
Cetrimonium-d₉ (bromide) is the deuterium labeled Cetrimonium bromide[1]. Cetrimonium bromide (CTAB) is an amine based cationic quaternary surfactant, is one of the components of the topical antiseptic Cetrimide.

HY-B1290S1

2-Phenylethanol-d9

2-Phenylethanol-d₉ is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.

HY-B1431S2

Butylparaben-d9

Butylparaben-d₉ (Butyl parahydroxybenzoate-d₉; Butyl paraben-d₉) is a deuterium labeled Butylparaben (HY-B1431).

HY-15459S1

Cabazitaxel-d9
Cabazitaxel-d₉ is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

HY-116790BS

(±)-Penbutolol-d9

(±)-Penbutolol-d₉ is the deuterium labeled (±)-Penbutolol[1].

HY-17501S

Bambuterol-d9 hydrochloride
Bambuterol-d₉ (hydrochloride) is the deuterium labeled Bambuterol. Bambuterol ((±)-Bambuterol) hydrochloride is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline.

HY-116790BSA

(±)-Penbutolol-d9 hydrochloride
(±)-Penbutolol-d₉ (hydrochloride) is a deuterium labeled (±)-Penbutolol hydrochloride. (+)-Penbutolol hydrochloride is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1].

HY-B1037S2

Salbutamol-d9
Salbutamol-d₉ is the deuterium labeled Salbutamol. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).

HY-B0269S

Rifapentine-d9

Rifapentine-d₉ is the deuterium labeled Rifapentine. Rifapentine (DL 473) is an antibiotic compound used in the treatment of tuberculosis.

HY-B1037S3

Salbutamol-d9 acetate
Salbutamol-d₉ (acetate) is the deuterium labeled Salbutamol[1]. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).

HY-14865S

Omadacycline-d9
Omadacycline-d9 (PTK 0796-d9; Amadacycline-d9) is the deuterium labeled Omadacycline (HY-14865) that can be used as the internal standard for the analysis of Omadacycline ^[1].

HY-10237S

Boceprevir-d9
Boceprevir-d₉ is the deuterium labeled Boceprevir. Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay[1][2][3][4][5]. Boceprevir inhibits SARS-CoV-2 3CLpro activity[6].

HY-113270AS

Actinine-d9 chloride
Actinine-d₉ chloride is the deuterium labeled Actinine chloride. Actinine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat[1][2].

HY-B0399S

L-Carnitine-d9

L-Carnitine-d₉ is the deuterium labeled L-Carnitine. L-Carnitine (Levocarnitine) is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2].

HY-17369BS

Tirofiban-d9

Tirofiban-d₉ is deuterium labeled Tirofiban.

HY-B0228S14

Adenosine-d9
Adenosine-d₉ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio ^[1] .

HY-B0739AS

Citicoline-d9 sodium
Citicoline-d₉ (sodium) is the deuterium labeled Citicoline sodium. Citicoline sodium salt is an intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes and also exerts neuroprotective effects.

HY-Y0453S

4-Carboethoxypiperidine-d9

4-Carboethoxypiperidine-d₉ is the deuterium labeled 4-Carboethoxypiperidine[1].
HY-N1446S5

Oleic acid-d9

Oleic acid-d₉ is deuterium labeled Oleic acid. Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator[1][2].

HY-17552S

sn-Glycero-3-phosphocholine-d9

sn-Glycero-3-phosphocholine-d₉ is the deuterium labeled sn-Glycero-3-phosphocholine. sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia[1][2].

HY-14660S

Dabrafenib-d9
Dabrafenib-d₉ is the deuterium labeled Dabrafenib. Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively[4].

HY-101952S1

Prostaglandin E2-d9
Prostaglandin E2-d₉ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-Y1088S2

Hydrocinnamic acid-d9
Hydrocinnamic acid-d₉ is the deuterium labeled Hydrocinnamic acid[1]. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activitie[2]s.

HY-N0111S2

Coenzyme Q10-d9

Coenzyme Q10-d₉ is the deuterium labeled Coenzyme Q10. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

HY-B2246S

L-Carnitine-d9 chloride

L-Carnitine-d₉ (chloride)e is the deuterium labeled L-Carnitine chloride. L-Carnitine chloride, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine chloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine chloride is an antioxidant. L-Carnitine chloride can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].

HY-Y0012S1

4-Butylaniline-d9

4-Butylaniline-d₉ is the deuterium labeled 4-Butylaniline[1].
HY-W062703S

(Rac)-Ruxolitinib-d9

(Rac)-Ruxolitinib D9 ((Rac)-INCB18424 D9) is the deuterium labeled (Rac)-Ruxolitinib. (Rac)-Ruxolitinib is a JAK2 inhibitor ^[1].

HY-12956S1

Dinoprost-d9
Dinoprost-d₉ is the deuterium labeled Dinoprost. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].

HY-Y0017S

L-Norleucine-d9
L-Norleucine-d₉ is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

HY-17380S

(S)-Timolol-d9 maleate

(S)-Timolol-d₉ (maleate) is deuterium labeled (S)-Timolol (Maleate). (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction[1][2][3].

HY-17496S

(R)-Timolol-d9 maleate

(R)-Timolol-d₉ (maleate) is deuterium labeled (R)-Timolol (maleate).
HY-N0684S1

Vitamin K1-d4

Vitamin K1-d₄ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1].

HY-D0184S5

2'-Deoxycytidine-13C9
2'-Deoxycytidine- ¹³C₉ (Deoxycytidine- ¹³C₉; Cytosine deoxyriboside- ¹³C₉; Deoxyribose cytidine- ¹³C₉) is ¹³C-labeled 2'-Deoxycytidine (HY-D0184). 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).

HY-125527S

Resolvin D1-d5

Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].

HY-W016389S

9H-Fluoren-2-ol-d9

9H-Fluoren-2-ol-d₉ (NSC 31248-d₉) is a deuterium labeled compound.

HY-B0803S1

Lumefantrine-d9
Lumefantrine-d₉ is the deuterium labeled Lumefantrine. Lumefantrine is an antimalarial drug, used in combination with Artemether. The artemether-lumefantrine (AL) as the first- and second-line anti-malarial drugs.

HY-B0282S1

Acetylcholine-d9 chloride

Acetylcholine-d₉ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-131104AS

Brombuterol-d9 hydrochloride

Brombuterol-d₉ (hydrochloride) is a deuterium labeled Brombuterol hydrochloride. Brombuterol hydrochloride is a β-adrenergic receptor agonist[1].

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